“CT textural analysis of abdominal aortic aneurysms as a biomarker for aneurysm growth – Rajani NK et al” published in The Lancet, Volume 383, Page S87, 26 February 2014
Size of abdominal aortic aneurysm (AAA) is just one of the components that accounts for rate of expansion or risk of rupture. Heterogeneity of the AAA could provide additional important (missing-link) biomarker information regarding aneurysm growth. CT texture analysis (CTTA) could quantify heterogeneity within standard CT images.
A recent work undertaken by Dr James Rudd’s group at the Division of Cardiovascular Medicine at the University of Cambridge demonstrated that CTTA undertaken using the TexRAD software can provide useful prognostic information about AAA.
In Particular the work highlights a greater AAA heterogeneity was linked to increase in annual AAA.expansion and identified patients who needed intervention (i.e. surgery). Furthermore results demonstrated that CT heterogeneity might also be linked to FDG PET signal (a marker of AAA inflammation). They concluded that the CTTA parameters from TexRAD software can be derived from standard routinely acquired CT images, potentially providing a straightforward and cost-effective means for risk-stratification.
Dr. James Rudd’s research was funded by the National Institute for Health Research (NIHR), Higher Education Funding Council for England.
Full abstract of the study is available from the following link: